Product Name :
Phospho-BCAR1 (Y410) Recombinant Rabbit Monoclonal Antibody [JE47-97]
Predicted band size :
93 kDa
Observed band size :
130 kDa
Synonyms:
BCAR 1 antibody Bcar1 antibody BCAR1_HUMAN antibody Breast cancer anti estrogen resistance 1 antibody Breast cancer anti estrogen resistance 1 protein antibody Breast cancer anti-estrogen resistance protein 1 antibody CAS antibody Cas scaffolding protein family member 1 antibody CAS1 antibody Cass1 antibody 展开
Function :
Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene. BCAR1 is a ubiquitously expressed adaptor molecule originally identified as the major substrate of v-Src and v-Crk . p130Cas/BCAR1 belongs to the Cas family of adaptor proteins and can act as a docking protein for several signalling partners. Due to its ability to associate with multiple signaling partners, p130Cas/BCAR1 contributes to the regulation to a variety of signaling pathways leading to cell adhesion, migration, invasion, apoptosis, hypoxia and mechanical forces. p130Cas/BCAR1 plays a role in cell transformation and cancer progression and alterations of p130Cas/BCAR1 expression and the resulting activation of selective signalling are determinants for the occurrence of different types of human tumors.(2-Cyanopyridin-3-yl)boronic acid Price
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phosphopeptide corresponding to residues surrounding Tyr410 of Human BCAR1.SulfoxFluor manufacturer
Species reactivity:
Human
Verify application:
WB
Coupling :
unconjugated
Clone number:
JE47-97
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33619066 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 93 kDa
Positive control :
HeLa cell lysate, HeLa treated with 1mM sodium orthovanadate for 30 minutes cell lysate.