Product Name :
PCK1 Recombinant Rabbit Monoclonal Antibody [JU84-39]
Predicted band size :
Observed band size :
Synonyms:
cytosolic [GTP] antibody GTP antibody PCK1 antibody PCKGC_HUMAN antibody PEP carboxykinase antibody PEPCK-C antibody PEPCK1 antibody PEPCKC antibody Phosphoenolpyruvate carboxykinase 1 (soluble) antibody Phosphoenolpyruvate carboxykinase 1 antibody 展开
Function :
Normal adjustment to changes in blood glucose levels depends on insulin signaling as well as enzymes involved in the regulation of gluconeogenesis. Pathological changes to this process are central to the type 2 diabetes phenotype. Phosphoenolpyruvate carboxykinase (PEPCK) plays an important role in this process by stimulating hepatic glucose production. PEPCK expression increases in response to glucagon and glucocorticoids, while insulin suppresses expression. Modulation of the signals governing PEPCK levels present a potential therapeutic approach to the treatment of insulin resistance and consequently obesity. The cytosolic form of PEPCK, known as PEPCK-C, and the mitochondrial form, known as PEPCK-M, are encoded by two different nuclear genes in mouse, human and chicken.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human PCK1 aa 26-75 / 622.BuySalicylic acid (potassium)
Species reactivity:
Human
Verify application:
IF-Cell, IHC-P, WB
Coupling :
unconjugated
Clone number:
JU84-39
RRID:
AB_3070700
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Dibutyl sulfide site Aliquot store at -20℃ or -80℃.PMID:33667720 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
69 kDa
Positive control :
293T, HepG2, SH-SY5Y, human liver tissue, human kidney tissue.