Product Name :
PTGR1 Recombinant Rabbit Monoclonal Antibody [PSH02-12]
Predicted band size :
36 kDa
Observed band size :
36 kDa
Synonyms:
15-oxoprostaglandin 13-reductase antibody FLJ99229 antibody leukotriene B4 12-hydroxydehydrogenase antibody LTB4DH antibody MGC34943 antibody NADP-dependent leukotriene B4 12-hydroxydehydrogenase antibody PGR1 antibody PRG-1 antibody Prostaglandin reductase 1 antibody Ptgr1 antibody 展开
Function :
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). atalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles.Price of 199105-03-8
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within human PTGR1 aa 1-329 / 329.Price of 6-Bromo-2-fluoro-3-methoxypyridine
Species reactivity:
Human, Rat, Mouse
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
PSH02-12
RRID:
AB_3072883
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33617355 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 36 kDa
Positive control :
HT-29 cell lysate, A549 cell lysate, SiHa cell lysate, A431 cell lysate, rat kidney tissue lysate, rat liver tissue lysate, human small intestine tissue, HeLa.