Lation is indispensable for p53 activation. Cell. 2008; 133:612?26. [PubMed: 18485870] 41. Martins CP, Brown-Swigart L, Evan GI. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell. 2006; 127:1323?334. [PubMed: 17182091] 42. Endo-Streeter S, Tsui MK, Odom AR, Block J, York JD. Structural research and protein engineering of inositol phosphate multikinase. J Biol Chem. 2012; 287:35360?5369. [PubMed: 22896696] 43. Holmes W, Jogl G. Crystal structure of inositol phosphate multikinase two and implications for substrate specificity. J Biol Chem. 2006; 281:38109?8116. [PubMed: 17050532] 44. Saiardi A, Nagata E, Luo HR, Sawa A, Luo X, Snowman AM, Snyder SH. Mammalian inositol polyphosphate multikinase synthesizes inositol 1,four,5-trisphosphate and an inositol pyrophosphate. Proc Natl Acad Sci USA. 2001; 98:2306?311. [PubMed: 11226235] 45. Morrison BH, Bauer JA, Hu J, Grane RW, Ozdemir AM, Chawla-Sarkar M, Gong B, Almasan A, Kalvakolanu DV, Lindner DJ. Inositol hexakisphosphate kinase two sensitizes ovarian carcinoma cells to various cancer therapeutics. Oncogene. 2002; 21:1882?889. [PubMed: 11896621] 46. Morrison BH, Haney R, Lamarre E, Drazba J, Prestwich GD, Lindner DJ. Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Oncogene. 2009; 28:2383?392. [PubMed: 19430495] 47. Koldobskiy MA, Chakraborty A, Werner JK Jr, Snowman AM, Juluri KR, Vandiver MS, Kim S, Heletz S, Snyder SH.(S)-3-Phenylmorpholine Chemical name p53-mediated apoptosis demands inositol hexakisphosphate kinase-2.Piperazine-2,6-dione site Proc Natl Acad Sci USA. 2010; 107:20947?0951. [PubMed: 21078964] 48. Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ. Inositol hexakisphosphate kinase two mediates development suppressive and apoptotic effects of interferon- in ovarian carcinoma cells. J Biol Chem. 2001; 276:24965?4970. [PubMed: 11337497] 49. Bosch D, Saiardi A. Arginine transcriptional response doesn’t need inositol phosphate synthesis. J Biol Chem.PMID:33721362 2012; 287:38347?8355. [PubMed: 22992733] 50. Dubois E, Dewaste V, Erneux C, Messenguy F. Inositol polyphosphate kinase activity of Arg82/ ArgRIII is just not expected for the regulation from the arginine metabolism in yeast. FEBS Lett. 2000; 486:300?04. [PubMed: 11119723] 51. El Alami M, Messenguy F, Scherens B, Dubois E. Arg82p is usually a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. Mol Microbiol. 2003; 49:457?68. [PubMed: 12828642]NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptSci Signal. Author manuscript; available in PMC 2014 July 23.Xu et al.Page52. Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A. p53 mediates cellular dysfunction and behavioral abnormalities in Huntington’s illness. Neuron. 2005; 47:29?1. [PubMed: 15996546] 53. Cheng T, Liu D, Griffin JH, Fern dez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003; 9:338?42. [PubMed: 12563316] 54. Watson PJ, Fairall L, Santos GM, Schwabe JW. Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Nature. 2012; 481:335?40. [PubMed: 22230954] 55. Nowak DE, Tian B, Brasier AR. Two-step cross-linking process for identification of NF-B gene network by chromatin immunoprecipitation. Biotechniques. 2005; 39:715?25. [PubMed: 16315372] 56. Colell A, Ricci JE,.