Product Name :
TRAF2 Recombinant Rabbit Monoclonal Antibody [SD205-06]
Predicted band size :
56 kDa
Observed band size :
53 kDa
Synonyms:
E3 ubiquitin-protein ligase TRAF2 antibody MGC:45012 antibody OTTHUMP00000022625 antibody OTTHUMP00000064745 antibody TNF receptor associated factor 2 antibody TNF receptor-associated factor 2 antibody TNF receptor-associated protein antibody TRAF 2 antibody TRAF2 antibody TRAF2_HUMAN antibody 展开
Function :
Tumor necrosis factor (TNF)-activated cell signaling is mediated primarily through the TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF-R2. Both TNF receptors are members of the expanding TNF receptor superfamily, which includes the FAS antigen and CD40.[Ir[dF(CF3)2ppy]2(bpy)]PF6 site Potential insight into an understanding of TNF receptor-mediated signaling was provided by the identification of two related proteins, TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively). Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2.Price of 6-Amino-1-hexyne A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40.PMID:33529492 The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a “TRAF-C” domain that is necessary and sufficient for CD40 binding and homodimerization.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within N-terminal human TRAF2.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Tissue, IHC-P, IP
Coupling :
unconjugated
Clone number:
SD205-06
RRID:
AB_3070123
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 56 kDa
Positive control :
HeLa cell lysate, K-562 cell lysate, C2C12 cell lysate, mouse liver tissue lysate, rat liver tissue lysate, human kidney tissue, human pancreas tissue, human liver tissue, mouse placenta tissue.