p40 Recombinant Rabbit Monoclonal Antibody [PDH0-02]

Function :
p63 protein (p63) is a nuclear protein, a transcription factor. The p40 is an isoform of p63, a transcription factor that regulates many cell activities, including cell proliferation, maintenance, and differentiation. It performs as a sensitive and specific tool for aiding in the identification of squamous cell carcinoma of the lung. In addition to its utility as a squamous differentiation marker, p40 has also been proven to be a valuable marker for highlighting myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland. Strong p40 expression is frequently observed in esophageal cancerous squamous lesions. Immunohistochemical detection of p40 can also be helpful in identifying urothelial carcinoma. In cases of prostate carcinoma, p40 is almost always found to be negative for basal cell staining. Among carcinomas, p40 has approximately the same sensitivity as p63 but a higher specificity, as the TAp63 isoform is expressed more widespread in eg., adenocarcinomas. Moreover, p63 occur in lymphomas that are p40 negative. Placenta is recommended as positive tissue control for p40, where an at least weak to moderate, distinct nuclear staining reaction of cytotrophoblasts must be seen. The cytotrophoblasts should be visible even at low magnification (5x objective). Supportive to placenta, tonsil can be used as positive and negative tissue control. Virtually all squamous epithelial cells must show a moderate to strong, distinct nuclear staining reaction. No nuclear or cytoplasmic staining reaction should be seen in other cell types.