Identified and chosen by searching the databases, Medline (1990 to July 2013), Embase (1990 to July 2012), Cochrane controlled trials register (Cochrane Library Problem 2, 2013), Web of Science (1990 to July 2013), PubMed (updated to July 2013) and Chinese Biomedical Literature Database (1989 to July 2013) below the search term “ilaprazole”. We also performed a complete manual search from the bibliographies of every single peerreviewed paper selected. No language or date limitations have been imposed. In addition, there was no limitation in publication type. Study choice criteria The choice criteria for inclusion within the metaanalysis have been: (1) RCT comparing ilaprazole 10 mg/d as well as other PPIs inside the therapy of duodenal ulcers; (two) duodenal ulcers will have to have already been diagnosed by upper gastrointestinal endoscopy; (3) the individuals ought to not acquire other medical therapies just before the trial, except the common triple therapy for Helicobacter pylori (H. pylori) eradication; and (4) the duration of your trials needs to be four wk, and ulcer healing was also assessed by endoscopy just after 4 wk of therapy. The decision to involve or exclude any trial was produced by two researchers separately. The two lists have been comRESULTSDescription of selected studies The search approach generated 32 studies. From these, we identified five trials involving 1481 patients comparing ilaprazole with other PPIs within the treatment of duodenal ulcer, which fulfilled the criteria for the metaanalysis.(S)-1-(4-Bromopheny)ethylamine Chemscene Four papers were published as peerreviewed articles, and a single as a meeting abstract[18]. 4 had been published in English plus the other was published in Chinese[19]. The baseline traits in the five articles are listed in Table 1. All of the trials had been according to intentiontotreat evaluation. All trials had been of high quality except one[18] (Table 1). The outcomes of the 5 trials are shown in Table 2[1719,23,24]. Metaanalysis We 1st compared ilaprazole in the regular dose 10 mg/d with other PPIs around the 4wk healing price and rate of adverse effects (Figure 1).Vanadium(IV)bis(acetylacetonato)oxide site There was no statistical heterogeneity inside the 4wk healing price among the five trials andWJG|www.PMID:23554582 wjgnet.comMay 7, 2014|Volume 20|Challenge 17|Ji XQ et al . Efficacy of ilaprazole for duodenal ulcersTable 1 Baseline qualities of trials incorporated inside the metaanalysisRef. Ho et al[17], 2009 Zhou et al[19], 2009 Song et al[18], 2010 Wang et al[23], 2011 Wang et al[24], 2012 Language English Chinese English English English Publication sort Full text Full text Abstract Full text Complete text Time 20022004 20052006 Not reported 20042005 20052006 Sufferers (n ) 202 510 156 117 496 Duration (wk) four four four 4 four Jadad score five five 2 5Table two Results of the randomized controlled trials with intentiontotreat analysisRef. Ho et al , 2009 Zhou et al[19],2009 Song et al[18], 2010 Wang et al[23], 2011 Wang et al[24],[17]10 mg/d and omeprazole (RR = 1.02; 95 CI: 0.981.07; Z = 1.16; P = 0.25).Regimen I 10 mg/d O 20 mg/d I ten mg/d O 20 mg/d I ten mg/d E 40 mg/d I ten mg/d O 20 mg/d I 10 mg/d O 20 mg/d4wk healing rate 78.6 (77/98) 78.8 (82/104) 90.three (307/340) 87.6 (149/170) 85.9 (67/78) 87.two (68/78) 93.1 (54/58) 89.8 (53/59) 95.0 (307/331) 90.0 (149/165)Price of adverse effects 23.5 (23/98) 22.1 (23/104) eight.two (28/340) 11.two (19/170) six.four (5/78) 7.five (6/78) six.9 (4/58) 13.six (8/59) 8.5 (28/331) 11.six (19/165)DISCUSSIONPPIs are very powerful medicines widely used in the management of peptic diseases including gastric and duodenal ulcers, gastroesophageal reflux disease and Zolling.